Windows Registry Editor Version 5.00 ; Changes to make TB Portable the default e-mail client ; Make your TB Portable the default mail client: Tools > Options. Don’t skip this step. ; Edit YOUR ThunderbirdPortable.exe path below. MINE is E:\\Program Files\\ThunderbirdPortable\\ThunderbirdPortable.exe ; Run this patch and you are done. [HKEY_LOCAL_MACHINE\SOFTWARE\Clients\Mail\Mozilla Thunderbird\shell\open\command] @="\"Z:\\Apps\\PortableThunderbird\\PortableThunderbird.exe\" -mail" [HKEY_LOCAL_MACHINE\SOFTWARE\Clients\Mail\Mozilla Thunderbird\shell\properties] @="Thunderbird &Options" [HKEY_LOCAL_MACHINE\SOFTWARE\Clients\Mail\Mozilla Thunderbird\shell\properties\command] @="\"Z:\\Apps\\PortableThunderbird\\PortableThunderbird.exe\" -options" [HKEY_LOCAL_MACHINE\SOFTWARE\Classes\mailto\DefaultIcon] @="Z:\\Apps\\PortableThunderbird\\App\\thunderbird\\thunderbird.exe,0" [HKEY_LOCAL_MACHINE\SOFTWARE\Classes\mailto\shell\open\command] @="\"Z:\\Apps\\PortableThunderbird\\PortableThunderbird.exe\" \"%1\"" [HKEY_LOCAL_MACHINE\SOFTWARE\Clients\Mail] @="Mozilla Thunderbird" ; This fixes MAPI [HKEY_LOCAL_MACHINE\SOFTWARE\Classes\CLSID\{29F458BE-8866-11D5-A3DD-00B0D0F3BAA7}\LocalServer32] @="Z:\\Apps\\PortableThunderbird\\PortableThunderbird.exe /MAPIStartUp"